Current Opinion in Biotechnology
Current Opinion in Biotechnology
5 years ago

A short history of RubisCO: the rise and fall (?) of Nature's predominant CO2 fixing enzyme

A short history of RubisCO: the rise and fall (?) of Nature's predominant CO2 fixing enzyme
Ribulose-1,5-bisphosphate carboxylase/oxygenase (RubisCO) is arguably one of the most abundant proteins in the biosphere and a key enzyme in the global carbon cycle. Although RubisCO has been intensively studied, its evolutionary origins and rise as Nature's most dominant carbon dioxide (CO2)-fixing enzyme still remain in the dark. In this review we will bring together biochemical, structural, physiological, microbiological, as well as phylogenetic data to speculate on the evolutionary roots of the CO2-fixation reaction of RubisCO, the emergence of RubisCO-based autotrophic CO2-fixation in the context of the Calvin cycle, and the further evolution of RubisCO into the ‘RubisCOsome’, a complex of various proteins assembling and interacting with the enzyme to improve its operational capacity (functionality) under different biological and environmental conditions.

Publisher URL: www.sciencedirect.com/science

DOI: S095816691730099X

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