Journal of the American Heart Association
Journal of the American Heart Association
5 years ago

Beneficial Effect of Mas Receptor Deficiency on Vascular Cognitive Impairment in the Presence of Angiotensin II Type 2 Receptor.

Jitsuo Higaki, Akinori Higaki, Masatsugu Horiuchi, Harumi Kan-No, Jun Iwanami, Masayoshi Kukida, Kana Tsukuda, Masaki Mogi, Toshifumi Yamauchi, Shuntaro Ikeda, Li-Juan Min, Bao-Shuai Shan, Hui-Yu Bai
The classical renin-angiotensin system is known as the angiotensin (Ang)-converting enzyme/Ang II/Ang type 1 receptor axis, which induces various organ damage including cognitive decline. The angiotensin-converting enzyme 2/Ang-(1-7)/Mas axis is known to exert antagonistic actions against the classical renin-angiotensin system axis in the cardiovascular system. However, its roles in the brain remain unclear. We examined possible roles of the angiotensin-converting enzyme 2/Ang-(1-7)/Mas axis in cognitive function, employing vascular cognitive impairment model mice.

Publisher URL: http://doi.org/10.1161/JAHA.117.008121

DOI: 10.1161/JAHA.117.008121

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