Blood
Blood
5 years ago

B-cell targeting in chronic Graft-versus-Host disease.

Robert Zeiser, Stefanie Sarantopoulos, Bruce R Blazar
Over the last decade our understanding of the pathophysiology of chronic graft-versus-host disease (cGVHD) has improved considerably. In this spotlight, we discuss emerging insights into the pathophysiology of cGVHD with a focus on B-cells. First, we summarize supporting evidence derived from mouse and human studies. Next, novel cGVHD therapy approaches that target B-cells will be covered to provide treating physicians with an overview of the rationale behind the emerging armamentarium against cGVHD.

Publisher URL: http://doi.org/10.1182/blood-2017-11-784017

DOI: 10.1182/blood-2017-11-784017

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