Journal of Clinical Epidemiology
Journal of Clinical Epidemiology
5 years ago

GRADE Guidelines: 19. Assessing the certainty of evidence describing the relative importance of outcomes or values and preferences -- Risk of bias and indirectness

The GRADE working group defines patient values and preferences as the relative importance patients place on the main health outcomes. We provide GRADE guidance for assessing the risk of bias and indirectness domains for certainty of evidence about the relative importance of outcomes. Study Design and Setting We applied the GRADE domains to rate the certainty of evidence in the importance of outcomes to several systematic reviews, iteratively reviewed draft guidance and consulted GRADE members and other stakeholders for feedback. Results This is the first of two articles. A body of evidence addressing the importance of outcomes starts at “high certainty”; concerns with risk of bias, indirectness, inconsistency, imprecision and publication bias lead to downgrading to moderate, low or very low certainty. We propose subdomains of risk of bias as selection of the study population, missing data, the type of measurement instrument, and confounding; we have developed items for each subdomain. The population, intervention, comparison and outcome (PICO) elements associated with the evidence determine the degree of indirectness. Conclusion This article provides guidance and examples for rating risk of bias and indirectness for a body of evidence summarizing the importance of outcomes.

Publisher URL: www.sciencedirect.com/science

DOI: S0895435617310363

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