Chemical Reviews
Chemical Reviews
5 years ago

Methods Utilizing First-Row Transition Metals in Natural Product Total Synthesis

Methods Utilizing First-Row Transition Metals in Natural Product Total Synthesis
Joshua E. Zweig, Timothy R. Newhouse, Daria E. Kim
First-row transition-metal-mediated reactions constitute an important and growing area of research due to the low cost, low toxicity, and exceptional synthetic versatility of these metals. Currently, there is considerable effort to replace existing precious-metal-catalyzed reactions with first-row analogs. More importantly, there are a plethora of unique transformations mediated by first-row metals, which have no classical second- or third-row counterpart. Herein, the application of first-row metal-mediated methods to the total synthesis of natural products is discussed. This Review is intended to highlight strategic uses of these metals to realize efficient syntheses and highlight the future potential of these reagents and catalysts in organic synthesis.

Publisher URL: http://dx.doi.org/10.1021/acs.chemrev.6b00833

DOI: 10.1021/acs.chemrev.6b00833

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