Organic Letters
Organic Letters
5 years ago

Photofluorination of Aliphatic C–H Bonds Promoted by the Phthalimide Group

Photofluorination of Aliphatic C–H Bonds Promoted by the Phthalimide Group
Yoshitaka Hamashima, Hiromichi Egami, Shuya Masuda, Yuji Kawato
Aliphatic C–H fluorination of phthalimide derivatives with Selectfluor was investigated under photoirradiation conditions. The reaction did not require any additive or catalyst and afforded C–H fluorinated products in moderate to good yields. It is likely that the reaction site depends on the C–H bond energy, and this may be the reason for the good to high regioselectivity.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.8b00133

DOI: 10.1021/acs.orglett.8b00133

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