Chemical Reviews
Chemical Reviews
5 years ago

Cyclopropanation Strategies in Recent Total Syntheses

Cyclopropanation Strategies in Recent Total Syntheses
Erick M. Carreira, Christian Ebner
Complex molecular architectures containing cyclopropanes present significant challenges for any synthetic chemist. This review aims to highlight the strategic considerations for introduction of the cyclopropane motif in a collection of recent total syntheses. At first, an overview of the most important and widely used cyclopropanation techniques is presented, followed by a discussion of elegant approaches and clever solutions that have been developed to enable the synthesis of various unique cyclopropane natural products or use of cyclopropanes as versatile strategic intermediates.

Publisher URL: http://dx.doi.org/10.1021/acs.chemrev.6b00798

DOI: 10.1021/acs.chemrev.6b00798

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