4 years ago

A Chemoselective N-Arylation Reaction of 2-Aminopyridine Derivatives with Arynes

A Chemoselective N-Arylation Reaction of 2-Aminopyridine Derivatives with Arynes
Hongbin Zhai, Bin Cheng, Taimin Wang, Yun Li, Xiaoguang Duan, Renqi Wang, Bing Zu, Jian Wei, Jianfei Zhao
A chemoselective N-arylation reaction of 2-aminopyridine derivatives with arynes in good to excellent yields has been described. The N-arylation products could be further applied to the facile construction of benzoisoquinuclidines and isoquinuclidines as well as pyrido[1,2-a]benzimidazoles.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b01405

DOI: 10.1021/acs.joc.7b01405

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