Journal of Organic Chemistry
Journal of Organic Chemistry
5 years ago

Active sp3 C–H Bond Oxidation Initiated sp3–sp2 Consecutive C–H Functionalization of N-Arylglycine Amides: Construction of Isatins

Active sp3 C–H Bond Oxidation Initiated sp3–sp2 Consecutive C–H Functionalization of N-Arylglycine Amides: Construction of Isatins
Xiaodong Jia, Yu Yuan, Yingzu Zhu, Honghe Ji, Jing Liu, Yu Shao
In the presence of catalytic triarylamine radical cation, an sp3–sp2 consecutive C–H functionalization of N-arylglycine amides was achieved, providing a series of isatin derivatives in high yields. In this transformation, the initial aerobic oxidation of the relatively active sp3 C–H bonds triggered the following intramolecular cyclization, in which the aniline group was employed as a removable auxiliary group to enable the consecutive process.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b01480

DOI: 10.1021/acs.joc.7b01480

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.