Formyloxyacetoxyphenylmethane as an N-Formylating Reagent for Amines, Amino Acids, and Peptides

5 years ago

Formyloxyacetoxyphenylmethane as an N-Formylating Reagent for Amines, Amino Acids, and Peptides

Jonathan M. J. Williams, Steven D. Bull, Ruth Lawrence, Robert S. L. Chapman

Formyloxyacetoxyphenylmethane is a stable, water-tolerant, N-formylating reagent for primary and secondary amines that can be used under solvent-free conditions at room temperature to prepare a range of N-formamides, N-formylanilines, N-formyl-α-amino acids, N-formylpeptides, and an isocyanide.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b02382

DOI: 10.1021/acs.orglett.7b02382

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