3 years ago

Copper- or Nickel-Enabled Oxidative Cross-Coupling of Unreactive C(sp3)–H Bonds with Azole C(sp2)–H Bonds: Rapid Access to β-Azolyl Propanoic Acid Derivatives

Copper- or Nickel-Enabled Oxidative Cross-Coupling of Unreactive C(sp3)–H Bonds with Azole C(sp2)–H Bonds: Rapid Access to β-Azolyl Propanoic Acid Derivatives
Xingrong Liao, Jingsong You, Luoqiang Zhang, Yang Shi, Guangying Tan, Yudong Yang, Yimin Wu
β-Azolyl propanoic acid derivatives are frequently found in biologically active molecules and pharmaceuticals. Here, we report the oxidative heteroarylation of unactivated C(sp3)–H bonds with azole C(sp2)–H bonds via copper or nickel catalysis with the aid of removable bidentate auxiliary, which provides a rapid pathway to β-azolyl propanoic acid derivatives. A variety of azoles such as oxazole, benzoxazole, thiazole, benzothiazoles, benzimidazole, purine, and even [1,2,4]triazolo[1,5-a]pyrimidine could be engaged in this protocol.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b02265

DOI: 10.1021/acs.orglett.7b02265

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.