3 years ago

C–H Functionalization of Azines

C–H Functionalization of Azines
Shuya Yamada, Takeshi Kaneda, Kenichiro Itami, Kei Murakami
Azines, which are six-membered aromatic compounds containing one or more nitrogen atoms, serve as ubiquitous structural cores of aromatic species with important applications in biological and materials sciences. Among a variety of synthetic approaches toward azines, C–H functionalization represents the most rapid and atom-economical transformation, and it is advantageous for the late-stage functionalization of azine-containing functional molecules. Since azines have several C–H bonds with different reactivities, the development of new reactions that allow for the functionalization of azines in a regioselective fashion has comprised a central issue. This review describes recent advances in the C–H functionalization of azines categorized as follows: (1) SNAr reactions, (2) radical reactions, (3) deprotonation/functionalization, and (4) metal-catalyzed reactions.

Publisher URL: http://dx.doi.org/10.1021/acs.chemrev.7b00021

DOI: 10.1021/acs.chemrev.7b00021

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