Chemical Reviews
Chemical Reviews
5 years ago

Unraveling the Thousand Word Picture: An Introduction to Super-Resolution Data Analysis

Unraveling the Thousand Word Picture: An Introduction to Super-Resolution Data Analysis
Antony Lee, Konstantinos Tsekouras, Carlos Bustamante, Christopher Calderon, Steve Pressé
Super-resolution microscopy provides direct insight into fundamental biological processes occurring at length scales smaller than light’s diffraction limit. The analysis of data at such scales has brought statistical and machine learning methods into the mainstream. Here we provide a survey of data analysis methods starting from an overview of basic statistical techniques underlying the analysis of super-resolution and, more broadly, imaging data. We subsequently break down the analysis of super-resolution data into four problems: the localization problem, the counting problem, the linking problem, and what we’ve termed the interpretation problem.

Publisher URL: http://dx.doi.org/10.1021/acs.chemrev.6b00729

DOI: 10.1021/acs.chemrev.6b00729

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