Clinical Cancer Research
Clinical Cancer Research
5 years ago

Targeting HSF1: a prime integrator of proteotoxic stress response in myeloma.

Samir Parekh
The HSF1 transcription factor is an integrator of the cellular stress response and its expression has demonstrated poor prognosis in multiple myeloma. Novel anti-HSF1 small molecule inhibitors CCT251236 and KRIB11 demonstrate in vitro and in vivo anti-myeloma activity, representing a novel approach for targeting the heat shock response in myeloma.

Publisher URL: http://doi.org/10.1158/1078-0432.CCR-18-0030

DOI: 10.1158/1078-0432.CCR-18-0030

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