Chemical Reviews
Chemical Reviews
4 years ago

Metal-Catalyzed Decarboxylative C–H Functionalization

Metal-Catalyzed Decarboxylative C–H Functionalization
Peng Hu, Min Zhang, Weiping Su, Ye Wei
C–H bond activation and decarboxylation are two significant processes in organic synthesis. The combination of these processes provides a novel synthetic strategy, that is, decarboxylative C–H bond functionalization. Considerable attention has been focused on such an active research field. This review offers an overview of the utility of decarboxylative C–H bond functionalization in the synthesis of various organic compounds, such as styrenes, chalcones, biaryls, and heterocycles, covering most of the recent advances of the decarboxylative functionalization of Csp–H, Csp2–H, and Csp3–H bonds, as well as their scopes, limitations, practical applications, and synthetic potentials.

Publisher URL: http://dx.doi.org/10.1021/acs.chemrev.6b00516

DOI: 10.1021/acs.chemrev.6b00516

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