Clinical Endocrinology
Clinical Endocrinology
5 years ago

The HDL anti-inflammatory function is impaired in the context of low-normal free thyroxine in diabetic and non-diabetic individuals

Robin P.F. Dullaart, Lynnda J.N. van Tienhoven-Wind, Uwe J. F. Tietge
Differences in thyroid function status within the euthyroid range have been proposed to affect the development of (subclinical) atherosclerosis [1], as evidenced by a greater carotid artery intima media thickness and progression of coronary artery calcification in the context of low normal thyroid function, i.e. a higher thyroid stimulating hormone (TSH) or a lower free thyroxine (FT4) thyroid hormone in the euthyroid range [2,3]. Importantly, with respect to high density lipoproteins (HDL) the concept is emerging that abnormalities in function rather than low concentrations of HDL cholesterol per se may give rise to impaired atheroprotective potential of this lipoprotein fraction. In line, a lower FT4 within the euthyroid range associates with a diminished ability of HDL to protect against LDL oxidation in vitro [4]. This article is protected by copyright. All rights reserved.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1111/cen.13570

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.