Tetrahedron
Tetrahedron
3 years ago

Highly regio- and stereoselective palladium-catalyzed allene bifunctionalization cascade via π-allyl intermediate

Highly regio- and stereoselective palladium-catalyzed allene bifunctionalization cascade via π-allyl intermediate
We report a palladium-catalyzed allene bifunctionalization reaction that forms CC and either CO or CN bonds in one pot with excellent regio- and stereoselectivity. Carboxylic acids, amides, and hydroxide are all suitable nucleophiles. Organoboronic acid acts as hydroxide transfer reagent. An intermediate π-allyl palladium complex was isolated, which yields improved catalytic performance as well as evidence of the origin of stereoselectivity. A derivatization study emphasizes the utility of the functionalized allylic products.

Publisher URL: www.sciencedirect.com/science

DOI: S0040402017308529

You might also like
Never Miss Important Research

Researcher is an app designed by academics, for academics. Create a personalised feed in two minutes.
Choose from over 15,000 academics journals covering ten research areas then let Researcher deliver you papers tailored to your interests each day.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.