Tetrahedron
Tetrahedron
5 years ago

Syntheses of CF2H-containing spirocyclopropyloxindoles from in situ generated CF2HCHN2 and 3-ylideneoxindoles

Syntheses of CF2H-containing spirocyclopropyloxindoles from in situ generated CF2HCHN2 and 3-ylideneoxindoles
A facile and practical [3+2] cycloaddition/ring contraction for the construction of structurally diverse CF2H-containing spirocyclopropyloxindoles was developed. Starting from isatin-derived 3-ylideneoxindoles and in situ generated CF2HCHN2, the desired products were obtained in good to excellent results (up to 99% yield and >99:1 trans/cis) in the absence of metal catalyst. The potential application of the protocol was also demonstrated by the synthesis of the CF2H-substituted analog of HIV-1 NNRTI inhibitor.

Publisher URL: www.sciencedirect.com/science

DOI: S0040402017308530

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.