Improve Solubility and Bioavailability of Silver Sulfadiazine via Formation of Inclusion Complex by Cyclodextrin
Abstract
Supramolecular nanocontainers of cyclodextrins (α-CD or β-CD)/silver sulfadiazine (SSD) were prepared by inclusion complex (IC) forming between CDs and SSD at various conditions (at room temperature and under sonic energy). Obtained nanocontainers were characterized by XRD, SEM, EDX and FTIR. Formation of inclusion complex was confirmed via significant differences between FTIR and XRD spectra of pure compounds with respect to those of the complexes. EDX analysis indicated the homogenous distribution of Ag nanoparticles in the nanocontainers. Solubility, bioavailability and in vitro dissolution of obtained SSD nanocontainers were compared with pure SSD and results show that by encapsulation of SSD, solubility improved and its release is controllable. Solubility and bioavailability of β-CD/SSD is higher than α-CD/SSD, which is related bigger β-CD cavity that can entrap a higher number of SSD molecules.
Publisher URL: https://link.springer.com/article/10.1007/s10904-018-0809-8
DOI: 10.1007/s10904-018-0809-8
Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.
Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.