Organic Letters
Organic Letters
5 years ago

Total Synthesis of (+)-Aplykurodinone-1

Total Synthesis of (+)-Aplykurodinone-1
Bo Xu, Fayang G. Qiu, Tingzhong Wang, Wen Xun
Starting from (R)-citronellic acid and (R)-seudenol, the total synthesis of (+)-aplykurodinone-1, a highly degraded marine steroid, has been achieved in 11 steps and in 19% overall yield with excellent stereochemical control. In addition to the features such as an Ireland–Claisen rearrangement, an intramolecular carbonyl–ene cyclization, and an intramolecular Michael addition, the present synthetic strategy is accomplished without the use of protecting groups.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b02350

DOI: 10.1021/acs.orglett.7b02350

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.