Current Medicinal Chemistry
Current Medicinal Chemistry
5 years ago

Metal-organic framework (MOF)-based nanomaterials for biomedical applications.

Zhidong Luo, Baohong Li, Shuran Fan, Weicong Liu, Chuying Gu, Jianqiang Liu
Metal-organic frameworks (MOFs) are compounds consisting of metal ions or clusters coordinated to organic ligands to form one-, two-, or three-dimensional structures. They are a subclass of coordination polymers (CPs), with the special feature that they are often porous. The organic ligands are sometimes referred to as second building structs. The new porous materials have paid great attention because of the variety of advantages such as tunable components, structural diversity, high loading performance and favorable biodegradability. In this review, we highlighted the recent progress on the drug delivery application of MOFs, especially emphasizing the application of pH-responsive delivery as well as magnetic-guided drug delivery systems (DDSs). Subsequently, the applications of MOFs in magnetic resonance imaging (MRI), optical imaging (OI), X-ray computed tomography (CT) imaging and multimodality imaging will be discussed. Finally, we will provide an overview for the photodynamic therapy and the toxicity feature of MOFs.

Publisher URL: http://doi.org/10.2174/0929867325666180214123500

DOI: 10.2174/0929867325666180214123500

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.