5 years ago

Prognostic and Pathogenic Role of Angiopoietin-1 and -2 in Pneumonia.

Timothy J Mitchell, Norbert Suttorp, Markus Scholz, Stefan Hippenstiel, Anne-Kathrin Neuhauß, Birgitt Gutbier, Stefano Aliberti, Lars Morawietz, Carolin Ehrler, Martin Witzenrath, Jörg Kaufmann, Ansgar Santel, Katrin Reppe, Norbert Weissmann
During pneumonia, pathogen-host interaction evokes inflammation and lung barrier dysfunction. Tie2-activation by Angiopoietin-1 reduces, while Tie2-blockade by Angiopoietin-2 increases inflammation and permeability during sepsis. The role of Angiopoietin-1/-2 in pneumonia remains unidentified.

Publisher URL: http://doi.org/10.1164/rccm.201708-1733OC

DOI: 10.1164/rccm.201708-1733OC

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