Journal of the American Society of Nephrology : JASN
Journal of the American Society of Nephrology : JASN
5 years ago

Renal Interstitial Platelet-Derived Growth Factor Receptor-βCells Support Proximal Tubular Regeneration.

Dominik Steppan, Maj-Kristina Hellmuth, Hayo Castrop, Katharina Fremter, Alexandra Grill, Ina Maria Schiessl
The kidney is considered to be a structurally stable organ with limited baseline cellular turnover. Nevertheless, single cells must be constantly replaced to conserve the functional integrity of the organ. PDGF chain B (PDGF-BB) signaling through fibroblast PDGF receptor-β(PDGFRβ) contributes to interstitial-epithelial cell communication and facilitates regenerative functions in several organs. However, the potential role of interstitial cells in renal tubular regeneration has not been examined.

Publisher URL: http://doi.org/10.1681/ASN.2017101069

DOI: 10.1681/ASN.2017101069

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