Nanotechnology
Nanotechnology
5 years ago

Origin of noise in liquid-gated Si nanowire troponin biosensors.

A Ivanchuk, Hanna Hlukhova, Yurii Kutovyi, Svetlana Vitusevich, Ihor Zadorozhnyi, Michail Petrychuk, Volodymyr Handziuk
Liquid-gated Si nanowire (NW) field-effect transistor (FET) biosensors are fabricated using a CMOS-compatible top-down approach. The transport and noise properties of the devices reflect the high performance of the FET structures, which allows label-free detection of cardiac troponin I (cTnI) molecules. Moreover, after removing the troponin antigen the structures demonstrate the same characteristics as before cTnI detection, indicating the reusable operation of biosensors. Our results show that the additional noise is related to the troponin molecules and has characteristics which considerably differ from those usually recorded for conventional FETs without target molecules. We describe the origin of the noise and suggest that noise spectroscopy represents a powerful tool for understanding molecular dynamic processes in nanoscale FET-based biosensors.

Publisher URL: http://doi.org/10.1088/1361-6528/aaaf9e

DOI: 10.1088/1361-6528/aaaf9e

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