Mediators of Inflammation
Mediators of Inflammation
5 years ago

Cigarette Smoke Exposure Inhibits Bacterial Killing via TFEB-Mediated Autophagy Impairment and Resulting Phagocytosis Defect.

Neeraj Vij, Kathryn Brucia, Garrett Pehote, Manish Bodas
Cigarette smoke (CS) exposure is the leading risk factor for COPD-emphysema pathogenesis. A common characteristic of COPD is impaired phagocytosis that causes frequent exacerbations in patients leading to increased morbidity. However, the underlying mechanism is unclear. Hence, we investigated if CS exposure causes autophagy impairment as a mechanism for diminished bacterial clearance via phagocytosis by utilizing murine macrophages (RAW264.7 cells) andPseudomonas aeruginosa(PA01-GFP) as an experimental model.

Publisher URL: http://doi.org/10.1155/2017/3028082

DOI: 10.1155/2017/3028082

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