ChemMedChem
ChemMedChem
5 years ago

Design, synthesis and biological evaluation of novel bivalent ligands targeting Dopamine D2-like receptors and µ opioid receptor

Patrick M. L. Vanderheyden, Kathleen Van Craenenbroeck, Martijn D. P. Risseeuw, Mingcheng Qian, Christophe Stove, Lakshmi Vasudevan, Jelle Huysentruyt, Serge Van Calenbergh
Nowadays, there is mounting evidence that intermolecular receptor-receptor interactions may result in altered receptor recognition, pharmacology and signaling. Heterobivalent ligands have been proven useful molecular probes for confirming and targeting heteromeric receptors. This paper describes the design and synthesis of novel heterobivalent ligands for dopamine D2-like receptors (D2-likeR) and the µ opioid receptor (µOR) and their evaluation using radioactive ligand binding and functional assays.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/cmdc.201700787

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