Obstetrical and Gynecological Survey
Obstetrical and Gynecological Survey
5 years ago

Metformin, the Aspirin of the 21st Century: Its Role in Gestational Diabetes Mellitus, Prevention of Preeclampsia and Cancer, and the Promotion of Longevity

Romero, Roberto, Pacora, Percy, Maymon, Eli, Yoon, Bo Hyun, Erez, Offer, Panaitescu, Bogdan, Grossman, Lawrence I., Conde-Agudelo, Agustin, Hüttemann, Maik
(Abstracted from Am J Obstet Gynecol 2017;217(3):282–302) Metformin (dimethylbiguanide hydrochloride) was initially introduced as an antidiabetic agent; however, in recent years, it has shown a wide array of beneficial effects ranging from cancer therapy to extending longevity. As a gestational antidiabetic agent, metformin has compared favorably to insulin by showing a significantly reduced frequency of neonatal hyperglycemia, large-for-gestational-age neonates, and admissions to a neonatal intensive care unit compared with those treated with insulin.

Publisher URL: https://journals.lww.com/obgynsurvey/Fulltext/2018/02000/Metformin,_the_Aspirin_of_the_21st_Century___Its.6.aspx

DOI: 10.1097/01.ogx.0000530433.33367.e9

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