Aflibercept Action in a Rabbit Model of Chronic Retinal Neovascularization: Reversible Inhibition of Pathologic Leakage With Dose-Dependent Duration.

Investigative Ophthalmology and Visual Science

5 years ago

Aflibercept Action in a Rabbit Model of Chronic Retinal Neovascularization: Reversible Inhibition of Pathologic Leakage With Dose-Dependent Duration.

Stanley J Wiegand, George D Yancopoulos, Jingtai Cao, Yang Liu, Thomas C MacPherson, Bibiana V Iglesias, Carmelo Romano, Natasha Tirko

We establish and characterize the chronic retinal neovascularization (RNV) induced by intravitreal (IVT) injection of DL-α-aminoadipic acid (AAA) in a rabbit model and investigate the extent and duration of inhibitory actions induced by IVT aflibercept on the RNV.

Publisher URL: http://doi.org/10.1167/iovs.17-22897

DOI: 10.1167/iovs.17-22897

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