HLA Class I Antigen Expression in Conjunctival Melanoma Is Not Associated With PD-L1/PD-1 Status.

Investigative Ophthalmology and Visual Science

5 years ago

HLA Class I Antigen Expression in Conjunctival Melanoma Is Not Associated With PD-L1/PD-1 Status.

Frans H J Claas, Marina Marinkovic, Niels J Brouwer, Nadine E de Waard, Jinfeng Cao, Martine J Jager, Bruce R Ksander, Sjoerd G van Duinen, Mirjam H M Heemskerk, Arend Mulder, Ekaterina S Jordanova

Antitumor T cells need expression of HLA class I molecules but can be inhibited by ligands such as programmed death ligand 1 (PD-L1). We determined expression and regulation of these molecules in human conjunctival melanoma (CM) samples, cell lines, and murine xenografts.

Publisher URL: http://doi.org/10.1167/iovs.17-23209

DOI: 10.1167/iovs.17-23209

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