Journal of Biological Chemistry
Journal of Biological Chemistry
5 years ago

Chaperone substrate provides missing link for cancer drug discovery.

Brian S J Blagg, Katherine M Byrd
Both Hsp70 and Hsp90 chaperones are overexpressed in cancer, making them relevant targets for the development of cancer chemotherapeutics, but a lack of biomolecular readouts for Hsp70 inhibition has limited the pursuit of specific inhibitors for this enzyme. A new study from Cesaet al.identifies two inhibitors of apoptosis proteins (IAPs) as specific client substrates of Hsp70. These results establish biomarkers that can be utilized to monitor Hsp70 inhibition and provide a framework for future efforts to deconvolute chaperone networks.

Publisher URL: http://doi.org/10.1074/jbc.H118.001591

DOI: 10.1074/jbc.H118.001591

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