Inorganic Chemistry
Inorganic Chemistry
5 years ago

An EXAFS Approach to the Study of Polyoxometalate–Protein Interactions: The Case of Decavanadate–Actin

An EXAFS Approach to the Study of Polyoxometalate–Protein Interactions: The Case of Decavanadate–Actin
Luís A. E. Batista de Carvalho, Manuel Aureliano, Diego Gianolio, Susana Ramos, M. Paula M. Marques
Decavanadate−actin interactions were studied by EXAFS and XANES, allowing us to simultaneously probe, for the first time, all vanadium species in the system. V10 interacts with G-actin (at its ATP binding site), a V−SCys coordination having been verified along with oxidovanadium formation. V10’s interplay with F-actin was found to be weak and occur via a different mechanism. These results are relevant for understanding V10’s biological roles, at a molecular level, aiming at potential pharmacological applications.

Publisher URL: http://dx.doi.org/10.1021/acs.inorgchem.7b01018

DOI: 10.1021/acs.inorgchem.7b01018

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.