Angewandte Chemie - International Edition
Angewandte Chemie - International Edition
5 years ago

Cyanide-Free and Broadly Applicable Enantioselective Synthetic Platform for Chiral Nitriles through a Biocatalytic Approach

Cyanide-Free and Broadly Applicable Enantioselective Synthetic Platform for Chiral Nitriles through a Biocatalytic Approach
Yasuhisa Asano, Harald Gröger, Tobias Betke, Keiko Oike, Philipp Rommelmann
A cyanide-free platform technology for the synthesis of chiral nitriles through biocatalytic enantioselective dehydration of a wide range of aldoximes leads to the nitrile products with high enantioselectivity in many cases. In their Communication (DOI: 10.1002/anie.201702952), Y. Asano, H. Gröger, and co-workers also describe an interesting phenomenon with regard to the enantiospecificity: Depending on whether the E or Z isomer of the racemic substrate is used, the opposite enantiomer of the nitrile is obtained with the same enzyme.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/anie.201707179

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