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5 years ago

Drug Delivery: Drug-Loaded Multifunctional Nanoparticles Targeted to the Endocardial Layer of the Injured Heart Modulate Hypertrophic Signaling (Small 33/2017)

Drug Delivery: Drug-Loaded Multifunctional Nanoparticles Targeted to the Endocardial Layer of the Injured Heart Modulate Hypertrophic Signaling (Small 33/2017)
Jarno Salonen, Vimalkumar Balasubramanian, Virpi Talman, Alexandra Correia, Sanjeev Ranjan, Sini Kinnunen, Ermei Mäkilä, Mónica P. A. Ferreira, Jouni Hirvonen, Marianna Kemell, Hélder A. Santos, Anu J. Airaksinen, Heikki Ruskoaho, Brianda Barrios-Lopez
Coronary heart disease is the main cause of death worldwide, the endocardium being the most vulnerable region for myocardial ischemia. In article number 1701276, by Mónica P. A. Ferreira, Heikki Ruskoaho, Anu J. Airaksinen, Hélder A. Santos, and co-workers, the development of a multifunctional nanoparticle with cardioprotective potential is reported, which selectively targets the endocardial layer of the left ventricle upon intravenous injection and delivers a drug molecule for modulating the hypertrophic signaling.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/smll.201770177

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