Crystal Growth & Design
Crystal Growth & Design
5 years ago

Dissolution of Bicalutamide Single Crystals in Aqueous Solution: Significance of Evolving Topography in Accelerating Face-Specific Kinetics

Dissolution of Bicalutamide Single Crystals in Aqueous Solution: Significance of Evolving Topography in Accelerating Face-Specific Kinetics
Leslie P. Hughes, Faduma M. Maddar, Stephen A. C. Wren, Patrick R. Unwin, Maria Adobes-Vidal
A combination of in situ atomic force microscopy and finite element method modeling reveals the surface processes that accompany dissolution of single bicalutamide microcrystals in real-time, highlighting the impact of topographical changes of a dissolving microcrystal on the overall dissolution kinetics.

Publisher URL: http://dx.doi.org/10.1021/acs.cgd.7b00401

DOI: 10.1021/acs.cgd.7b00401

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