Chemistry - A European Journal
Chemistry - A European Journal
5 years ago

An Aminocatalyzed Stereoselective Strategy for the Formal α-Propargylation of Ketones

An Aminocatalyzed Stereoselective Strategy for the Formal α-Propargylation of Ketones
Igor D. Jurberg
A two-step strategy has been developed for the stereoselective preparation of alpha-propargyl ketones using isoxazol-5-ones as key building blocks. The first step is an aminocatalyzed addition of ketones to alkylidene isoxazol-5-ones, whereas the second step is a controlled nitrosative degradation event that transforms the isoxazol-5-one ring into a triple bond. In this regard, the isoxazol-5-one ring can be seen as a masked alkyne. By removing the mask, a new universe is revealed. This metaphor is represented in the artwork. More information can be found in the Communication by I. D. Jurberg. (DOI: 10.1002/chem.201701433).

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/chem.201702050

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.