5 years ago

Structure, Biosynthesis, and Biological Activity of the Cyclic Lipopeptide Anikasin

Structure, Biosynthesis, and Biological Activity of the Cyclic Lipopeptide Anikasin
Helmar Görls, Thomas Burks, Robert Barnett, Martin Klapper, Regine Herbst-Irmer, Sebastian Götze, Ursula Neu, Kilian R. A. Schneider, Pierre Stallforth
The class of cyclic lipopeptide natural products consists of compounds with a diverse range of bioactivities. In this study, we elucidated the structure of the cyclic lipopeptide anikasin using X-ray crystallography, analyzed its biosynthetic gene cluster, and investigated its natural role in the interaction between the producer strain Pseudomonas fluorescens HKI0770 and protozoal predators. These results led to the conclusion that anikasin has dual functionality enabling swarming motility and acting as a niche amoebicide, which effectively inhibits the social amoeba Polysphondylium violaceum and protects the producer strain from protozoal grazing.

Publisher URL: http://dx.doi.org/10.1021/acschembio.7b00589

DOI: 10.1021/acschembio.7b00589

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