4 years ago

Discrimination of Saccharides by a Simple Array

Discrimination of Saccharides by a Simple Array
Uwe H. F. Bunz, N. Maximilian Bojanowski, Markus Bender, Kai Seehafer
We report the development of a two-component probe system as fluorescence turn-on assay of simple saccharides. The quenching of an anionic conjugated water-soluble polymer by a cationic quencher has been reported previously. Three different boronic acid functionalized benzyl viologens and three conjugated polymers of the poly(aryleneethynylene) type form nine non-fluorescent complexes. This small library discriminates nine different simple saccharides in aqueous solutions by fluorescence turn-on in a displacement assay. The saccharides can be discriminated and identified with this simple system. Simple sugar discrimination: A fluorescent turn-on assay, which incorporates poly(aryleneethynylene) polymers that discriminate and identify different saccharides through complex formation with different boronic acid substituted viologens, has been developed.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/chem.201700831

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