5 years ago

pH-Responsive Aminoproline-Containing Collagen Triple Helices

pH-Responsive Aminoproline-Containing Collagen Triple Helices
Christiane Siebler, Cedric Bergande, Helma Wennemers, Christian Ochsenfeld, Roman S. Erdmann, Jasmine Egli, Boris Maryasin
pH-Responsive aminoproline residues were used to tune the stability of collagen triple helices in acidic and basic environments. The position of the aminoproline residue within the triple helix and the absolute configuration at C(4) enabled tuning of the stability over a wide range. The results open opportunities for the development of stimuli-responsive collagen-based materials. More information can be found in the Full Paper by H. Wennemers et al. (DOI: 10.1002/chem.201701134).

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/chem.201702133

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