3 years ago

Guanosine-5′-Monophosphate Polyamine Hybrid Hydrogels: Enhanced Gel Strength Probed by z-Spectroscopy

Guanosine-5′-Monophosphate Polyamine Hybrid Hydrogels: Enhanced Gel Strength Probed by z-Spectroscopy
Juan A. Aguilar, Jonathan W. Steed, Raquel Belda, Enrique García-España, Gareth A. Morris
The self-assembling tendencies of guanosine-5′-monophosphate (GMP) can be drastically increased using polyamines, with potential applications in the production of biocompatible smart materials, as well as for the design of antitumor drugs based on G-quadruplex stabilization. Results from scanning electron microscopy (SEM), wide angle X-ray scattering (WAXS), rheology, and nuclear magnetic resonance (NMR) z-spectroscopy studies are presented. Some self-assembly required: The self-assembling tendencies of guanosine-5′-monophosphate (GMP) can be drastically increased using polyamines, with potential applications in the production of biocompatible smart materials, as well as in the design of antitumor drugs based on G-quadruplex stabilization.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/chem.201700642

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