5 years ago

Frontispiece: Double Sequential Encrypted Targeting Sequence: A New Concept for Bone Cancer Treatment

Frontispiece: Double Sequential Encrypted Targeting Sequence: A New Concept for Bone Cancer Treatment
Gonzalo Villaverde, Valentina Nairi, Alejandro Baeza, María Vallet-Regí
The efficacy of conventional chemotherapy is severely compromised by the associated systemic toxicity caused by lack of selectivity. In this work, we propose a novel double sequential encrypted targeting system that contains an active primary targeting group able to recognize the target tissue (bone) and an encrypted or hidden secondary targeting moiety able to recognize malignant cells that populate the diseased tissue. Once the system reaches the tumoral place, the presence of a characteristic enzyme naturally overproduced by malignant cells (cathepsin K) provokes the activation of the cellular targeting moiety inducing the uptake within the diseased cells. For more information, see the Communication by Vallet-Regí et al. on page 7174 ff.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/chem.201783062

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.