3 years ago

Impact of Tachyarrhythmia Detection Rate and Time From Detection to Shock on Outcomes in Nationwide U.S. Practice

Although higher detection rates and delayed detection improve survival in ICD clinical trials, their effectiveness in clinical practice has limited validation. In order to evaluate the effectiveness of programming strategies for reducing shocks and mortality we conducted a nationwide assessment of ICD/CRT-D patients with linked remote monitoring data. We categorized patients based upon the presence or absence of high rate detection and delayed detection: higher rate delayed detection (HRDD), higher rate early detection (HRED), lower rate delayed detection (LRDD), and lower rate early detection (LRED). Cox-regression was used to compare mortality and shock-free survival. There were 64,769 patients (age 68±12 years; 27% female; 46% CRT-D; follow-up 1.7±1.1 years). In the first year, 13% of HRDD, 14% of HRED, 18% of LRDD, and 20% in the LRED group experienced a shock. After adjustment, HRDD was associated with lower risk of shock than HRED (HR 0.93 [95% CI 0.89-0.98], p=0.002), LRDD (HR 0.63 [95% CI 0.60-0.66], p<0.001), and LRED (HR 0.58 [95% CI 0.55-0.61], p<0.001). HRDD was also associated with lower risk of mortality than HRED (adjusted HR 0.80 [95% CI 0.75-0.86], p<0.001), LRDD (HR 0.76 [95% CI 0.70-0.83], p<0.001), and LRED (HR 0.68 [95% CI 0.62-0.73], p<0.001). Similar results were observed in patients with or without a shock in the first 6 months after implant. In conclusion, rate programming is associated with lower risk of shocks or death compared with delayed detection. Optimal outcomes are observed in patients programmed with both high rate and delayed detection.

Publisher URL: www.sciencedirect.com/science

DOI: S0002914917311797

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