5 years ago

Impact of Supraventricular Tachyarrhythmia in Patients with Inherited Cardiac Arrhythmia

Supraventricular tachyarrhythmia (SVT) especially atrial fibrillation (AF) has been observed in patients with inherited cardiac arrhythmia (ICA). Data on the time course of SVT and the occurrence of other SVT than AF is limited. In this study, we examined the prevalence, co-existence and the time course of different types of SVT in patients with various ICAs. In this retrospective study, we selected 393 patients (median: 49 years, range:17-87, 57% male) from a cohort of patients visiting the outpatient clinic for cardiogenetic screening of ICA. Patients medical records were examined for the occurrence of AF and other SVT. AF/SVT were found in 49 patients (12%, 31 male 42±17 years). Patients presenting with only AF (N=12, 3%) were older than patients presenting with only SVT (N=28, 7%), respectively 52±18 versus 37±14, P=0.007. Nineteen patients (5%) had multiple episodes of either AF (N=7, 2%) or SVT (N=12, 3%). Alternating episodes of AF and SVT occurred in 9 patients (2%). Intervals between second and third AF episodes were significantly shorter than between first and second episodes (P=0.02). An implantable cardioverter defibrillator (ICD) was implanted in 158 patients (40.2%) and 26 patients (16%) had inappropriate ICD shocks (SVT:25, AF:1), particularly those with multiple SVT episodes (P=0.003). In patients with a variety of ICAs, episodes of AF/SVT occurred in 12%. In patients with multiple AF episodes, intervals between consecutive episodes became significantly shorter over time. AF/SVT episodes are associated with inappropriate ICD shocks and aggressive therapy of AF/SVT is therefore justified.

Publisher URL: www.sciencedirect.com/science

DOI: S0002914917313863

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