3 years ago

Highly nucleophilic vitamin B12-assisted nickel-catalysed reductive coupling of aryl halides and non-activated alkyl tosylates

Highly nucleophilic vitamin B12-assisted nickel-catalysed reductive coupling of aryl halides and non-activated alkyl tosylates
Itaru Osaka, Shinnosuke Kiguchi, Kimihiro Komeyama, Ryo Ohata
Reductive cross-coupling of aryl halides with alkyl tosylates was developed using a nickel/vitamin B12 catalyst system. The tosylate was activated by reduced vitamin B12 to form alkyl cobalt(III), which served as a good alkylating agent for aryl-nickel species, leading to C(sp3)-C(sp2) bond.

Publisher URL: http://feeds.rsc.org/~r/rss/CC/~3/Nt9dj7d6aIo/C7CC01932G

DOI: 2017/CC/C7CC01932G

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