4 years ago

Highly Efficient Self-Healable and Dual Responsive Cellulose-Based Hydrogels for Controlled Release and 3D Cell Culture

Highly Efficient Self-Healable and Dual Responsive Cellulose-Based Hydrogels for Controlled Release and 3D Cell Culture
Yen Wei, Lei Tao, Jinhua Guo, Liao Peng, Guoqiang Liu, Jinying Yuan, Lina Zhang, Chunyu Chang, Xuefeng Yang
To face the increasing demand of self-healing hydrogels with biocompatibility and high performances, a new class of cellulose-based self-healing hydrogels are constructed through dynamic covalent acylhydrazone linkages. The carboxyethyl cellulose-graft-dithiodipropionate dihydrazide and dibenzaldehyde-terminated poly(ethylene glycol) are synthesized, and then the hydrogels are formed from their mixed solutions under 4-amino-DL-phenylalanine (4a-Phe) catalysis. The chemical structure, as well as microscopic morphologies, gelation times, mechanical and self-healing performances of the hydrogels are investigated with 1H NMR, Fourier transform infrared spectroscopy, atomic force microscopy, rheological and compression measurements. Their gelation times can be controlled by varying the total polymer concentration or 4a-Phe content. The resulted hydrogels exhibit excellent self-healing ability with a high healing efficiency (≈96%) and good mechanical properties. Moreover, the hydrogels display pH/redox dual responsive sol-gel transition behaviors, and are applied successfully to the controlled release of doxorubicin. Importantly, benefitting from the excellent biocompatibility and the reversibly cross-linked networks, the hydrogels can function as suitable 3D culture scaffolds for L929 cells, leading to the encapsulated cells maintaining a high viability and proliferative capacity. Therefore, the cellulose-based self-healing hydrogels show potential applications in drug delivery and 3D cell culture for tissue engineering. New high-performance cellulose-based self-healing hydrogels are constructed through dynamic acylhydrazone crosslinking under 4-amino-dl-phenylalanine catalysis. These hydrogels have highly tunable gelation time and exhibit pH/redox controlled release behaviors. Importantly, they can serve as suitable 3D culture scaffolds for cells, as a result of their excellent biocompatibility and adaptable dynamic networks.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/adfm.201703174

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.