Advanced Functional Materials
Advanced Functional Materials
5 years ago

High-Yield Synthesis of Multifunctional Tellurium Nanorods to Achieve Simultaneous Chemo-Photothermal Combination Cancer Therapy

High-Yield Synthesis of Multifunctional Tellurium Nanorods to Achieve Simultaneous Chemo-Photothermal Combination Cancer Therapy
Wei Huang, Tianqi Nie, Tianfeng Chen, Yanyu Huang, Yuanyuan You
Tellurium (Te) is an important semiconductor material with low band-gap energy, which has attracted considerable attention in recent years, due to its special chemical and physical properties and wide potential in electrochemistry, optoelectronics, and biological fields. This study demonstrates a facile and high-yield synthesis strategy of Te nanorods (PTW-TeNRs) decorated by polysaccharide–protein complex, which can achieve simultaneous chemo-photothermal combination therapy against cancers. PTW-TeNRs alone possess high stability under physiological conditions, potent anticancer activities through induction of reactive oxygen species overproduction, and high selectivity among tumor and normal cells. More importantly, they exhibit strong near-infrared (NIR) absorbance and good photothermal conversion ability from NIR light to heat energy. Furthermore, in combination with NIR laser irradiation, PTW-TeNRs exhibit excellent chemo-photothermal efficiency and low toxicity as evidenced by highly efficient tumor ablation ability, but show no obvious histological damage to the major organs. Taken together, this study provides a valid tactic for facile synthesis of multifunctional tellurium nanorods for efficient and combinational cancer therapy. A facile and high-yield synthesis of multifunctional tellurium nanorods enables simultaneous chemo-photothermal combination cancer therapy.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/adfm.201701388

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.