Chemistry - An Asian Journal
Chemistry - An Asian Journal
5 years ago

Robust Acenaphthoimidazolylidene Palladacycles: Highly Efficient Catalysts for the Amination of N-Heteroaryl Chlorides

Robust Acenaphthoimidazolylidene Palladacycles: Highly Efficient Catalysts for the Amination of N-Heteroaryl Chlorides
Qinyue Deng, Haibo Zhu, Yang Zhang, Tao Tu
The perfect match: Challenging and selective amination of N-heteroaryl chlorides by diverse primary and secondary amines has been successfully realized by using robust and congested N-heterocyclic carbene palladacycles as catalysts. Furthermore, the coupling protocol is readily extended to synthesize rosiglitazone, a clinical drug for diabetes mellitus, highlighting its potential pharmaceutical feasibility. More information can be found in the Communication by Tao Tu et al. (DOI:10.1002/asia.201700877).

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/asia.201701055

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