4 years ago

cGAS Conducts Micronuclei DNA Surveillance

cGAS Conducts Micronuclei DNA Surveillance
Carina C. de Oliveira Mann, Philip J. Kranzusch

DNA damage elicits a potent proinflammatory immune response. A collection of four papers now reveals that micronuclear DNA is a new cell intrinsic immunostimulatory molecule, and that accumulation of the immune sensor cyclic GMP–AMP synthase (cGAS) in micronuclei leads to a cell-cycle-dependent proinflammatory response following DNA damage.

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