American Journal of Cardiology
American Journal of Cardiology
5 years ago

Correlation of Fractional Flow Reserve with Ischemic Burden Measured by Cardiovascular Magnetic Resonance Perfusion Imaging

Cardiovascular Magnetic Resonance (CMR) perfusion imaging and Fractional Flow Reserve (FFR) assess myocardial ischemia. FFR measures the pressure loss across a stenosis determining hemodynamic significance but does not assess the area subtended by the stenotic vessel. CMR perfusion imaging measures the extent of myocardial blood flow reduction (= ischemic burden). Both techniques allow for continuous rather than categorical evaluation but their relationship is poorly understood. This study investigates the relationship between the FFR value and the extent of myocardial ischemia. 49 patients with angina underwent CMR perfusion imaging. FFR was measured in vessels with a visual diameter stenosis >40%. The extent of ischemia for each coronary artery was measured by delineating the perfusion defect on the CMR images and expressing as a percentage of the LV myocardium. The correlation between the extent of ischemia measured by CMR and FFR was good (r = -0.85, p<0.0005). The mean FFR value was 0.67 ± 0.17 and the mean perfusion defect was 8.9 ± 9.3%. An FFR value of ≥0.75 was not associated with ischemia on CMR. The maximum amount of ischemia (23.0±1.5%) was found at FFR values between 0.4 - 0.5. In patients with one vessel disease (49%) the mean ischemic burden was 15.3±8.3%. In patients with 2 vessel disease (18%) the mean ischemic burden was 26.0±12%. Reproducibility for measurement of ischemic burden was very good with a Kappa coefficient (k=0.826, p=0.048). In conclusion, there is good correlation between the FFR value and the amount of myocardial ischemia in the subtended myocardium.

Publisher URL: www.sciencedirect.com/science

DOI: S0002914917313723

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.