Psychoneuroendocrinology
Psychoneuroendocrinology
5 years ago

A field study of the association between CD38 gene and altruistic behavior: Empathic response as a mediator

Inspired by the enhancement effects of oxytocin on empathic responses and altruistic behaviors, we conducted a field study with a real fundraising event and investigated to what extent oxytocin pathway genes (CD38 and OXTR) modulate individual differences in charitable donation. Participants were informed that a teacher in their university was diagnosed with uremia and could not afford the cost of medication. They were given the opportunity to donate any amount of money and report their empathic responses to the misfortune of the teacher. We found a significant association between CD38 rs3796863 and the amount of donation both before and after controlling for gender, age, subjective socioeconomic status, religious belief, and social desirability. Individuals with the genotypes (AA/AC) leading to higher oxytocin levels reported stronger empathic responses and donated more money than individuals with the CC genotype. Moreover, empathic response mediated the gene-altruism association. However, we observed no significant associations between the three polymorphisms of OXTR (rs53576, rs2254298, and rs1042778) and the amount of donation. This study demonstrates the importance of CD38 as a source of individual differences in altruistic behavior and highlights the role of empathic response in bridging the link between the oxytocin pathway gene and altruism.

Publisher URL: www.sciencedirect.com/science

DOI: S030645301730330X

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.