4 years ago

Blocking FSH induces thermogenic adipose tissue and reduces body fat

Blocking FSH induces thermogenic adipose tissue and reduces body fat
Victoria E. DeMambro, Solomon Epstein, Xingjian Zhang, Shozeb Haider, Jianhua Li, Maria I. New, Edward X. Guo, Samarth Dhawan, Yue Eric Yu, Ling-Ling Zhu, Aaron Brown, Clifford J. Rosen, Sudeh Izadmehr, Terry F. Davies, Yaoting Ji, Valeria Shnayder, Li Sun, Samuel T. Robinson, T. Rajendra Kumar, Rauf Latif, Ping Lu, Yu Zhou, Peng Liu, Bin Zhou, Douglas J. Oberlin, Narayan G. Avadhani, Christoph Buettner, Elizabeth Rendina-Ruedy, Jan B. van Klinken, Jameel Iqbal, Mone Zaidi, Andrew C. Shin, Wahid Abu-Amer, Priyanthan Thangeswaran, Henrik Molina, Tony Yuen, Feiran Yang, Michaela R. Reagan, Zhuan Bian, Animesh Gupta

Menopause is associated with bone loss and enhanced visceral adiposity. A polyclonal antibody that targets the β-subunit of the pituitary hormone follicle-stimulating hormone (Fsh) increases bone mass in mice. Here, we report that this antibody sharply reduces adipose tissue in wild-type mice, phenocopying genetic haploinsufficiency for the Fsh receptor gene Fshr. The antibody also causes profound beiging, increases cellular mitochondrial density, activates brown adipose tissue and enhances thermogenesis. These actions result from the specific binding of the antibody to the β-subunit of Fsh to block its action. Our studies uncover opportunities for simultaneously treating obesity and osteoporosis.

Publisher URL: http://dx.doi.org/10.1038/nature22342

DOI: 10.1038/nature22342

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